目的：心脏外科手术是治疗冠心病的有效手段之一，但术中常导致心包膜破损，引发心脏与周围组织的粘连，从而影响心功能及后续手术操作。本研究旨在开发一种可降解的人造心包膜，能够与心脏共型贴附，形成物理隔离层，并在缺血部位实现抗炎药物的缓释，从而同时达到防粘连、减轻心肌纤维化及炎症反应的目的。

方法：本研究设计了一种双层结构的防粘连载药心包膜。外层提供物理屏障，防止心肌组织与周围组织粘连，同时抑制胸腔炎性细胞的募集和成纤维细胞的迁移；内层负载秋水仙碱，作为药物缓释层，减轻缺血心肌的炎症反应和纤维化。通过在体和体外实验评估薄膜的抗炎、抗粘连及改善心功能的效果。该薄膜在遇水后质地柔软，可实现与心脏的良好贴附，并在撕离时对组织无损伤。

结果：研究结果显示，该薄膜具有良好的抗炎和术后防粘连效果，可抑制心脏成纤维细胞的增殖和迁移。免疫荧光染色证实其对炎性细胞的募集具有显著抑制作用。体外药物浓度检测表明双层结构可实现稳定的药物缓释。超声检测显示，该薄膜的植入有助于心梗后心功能的恢复。

结论：所开发的高分子共型贴附心包膜具备显著的抗粘连和抗炎作用，并对缺血后心功能的恢复具有积极促进作用，具有良好的临床应用潜力。

Purpose: Cardiac surgery is an effective treatment for coronary artery disease; however, it often causes pericardial damage, leading to adhesions between the heart and surrounding tissues. These adhesions compromise cardiac function and complicate subsequent surgical interventions. This study aims to develop a biodegradable artificial pericardium that conforms to the heart, forms a physical barrier, and provides controlled anti-inflammatory drug release at ischemic sites. The dual-purpose design seeks to prevent adhesions while reducing myocardial fibrosis and inflammation.

Methods: A dual-layer structure was designed for the anti-adhesion, drug-loaded pericardium. The outer layer serves as a physical barrier to prevent adhesion between myocardial tissues and surrounding structures while inhibiting the recruitment of inflammatory cells and migration of fibroblasts. The inner layer, loaded with colchicine, acts as a drug-release layer to alleviate inflammation and fibrosis in ischemic myocardium. The membrane’s anti-inflammatory, anti-adhesion, and cardiac function improvement effects were evaluated through in vitro and in vivo experiments. The membrane becomes soft upon hydration, adheres well to the heart, and can be removed without tissue damage.

Results: The membrane exhibited excellent anti-inflammatory and anti-adhesion effects, significantly inhibiting the proliferation and migration of cardiac fibroblasts. Immunofluorescence staining demonstrated its effective suppression of inflammatory cell recruitment. Drug release assays confirmed the stability of the dual-layer structure for controlled drug release. Ultrasound evaluations showed that the membrane implantation promoted post-myocardial infarction cardiac function recovery.

Conclusion: The developed polymer-based conformable pericardial membrane demonstrates significant anti-adhesion and anti-inflammatory properties, facilitating functional recovery of ischemic myocardium. These findings indicate promising potential for clinical applications.