随着老龄化的加剧和电子设备的滥用，越来越多的人患上眼科疾病，比如白内障、屈光不正（近视和老视）、青光眼以及眼底病变等。无论是在对白内障患者的手术治疗中，还是对近视、老视等屈光不正疾病的诊断中，均需要测量眼组织生物参数，尤其是眼轴长度和角膜曲率。眼组织参数测量在眼科疾病的诊断和治疗中具有重要的作用。

       在常用的生物组织参数测量方法中，无创、非接触、高分辨率的光学测量方法逐渐成为趋势。目前关于眼组织光学测量方法的实验研究取得了一定的进展，临床上已经有多款光学生物测量仪，但是目前仍有不成熟的地方，比如不能全眼成像，图像需要拼接，以及测量参数类型不全面等。针对以上问题，本文提出一种高分辨率、大量程成像、高精度测量的光学生物测量方法，为眼科疾病的诊断和治疗提供可靠手段。

       本文基于扫频源光学相干断层扫描技术研制全眼组织参数测量系统，用于全眼成像和精确测量眼组织参数。系统使用基于垂直腔表面发射激光技术的中心波长为1060 nm的扫频源激光器作为光源，并集成内固视组件和视频监视组件。通过C++编程控制系统扫描和同步采样，将采集的数据经数据采集卡上传至计算机进行处理，获得目标组织的空间结构信息，生成2D图像。

       本文使用全眼组织参数测量系统进行预实验及人眼组织参数测量实验。预实验主要测量模拟眼内各处标定的距离信息和平凸透镜的曲率信息。人眼测量实验主要分为测量眼轴长度等参数的长度测量实验及测量角膜屈光度的曲率测量实验。根据眼球结构和各组织折射率理论，在2D图像上测量长度及曲率，计算出对应的眼组织参数的数据。为了验证系统测量的准确性，将测量结果与IOL Master 700的测量数据进行对比分析。通过线性回归分析评估表明，本系统与IOL Master 700的测量结果具有一致性，说明研制的全眼组织参数测量系统准确地实现了眼轴长度和角膜曲率等眼组织参数的测量，满足临床测量要求，在眼科疾病的诊断和防治方面具有潜在的应用价值。

With the increase of aging and the abuse of electronic devices, more and more people suffer from eye diseases, such as cataracts, refractive errors (nearsightedness and presbyopia), glaucoma, and fundus diseases. Whether in the surgical treatment of cataract patients or in the diagnosis of refractive errors such as myopia and presbyopia, it is necessary to measure the biological parameters of the eye tissue, especially the axis length and the curvature of the cornea. The measurement of ocular tissue parameters is important for the diagnosis and treatment of ophthalmic diseases.

Among the commonly used methods for measuring biological tissue parameters, non-invasive, non-contact, and high-resolution optical measurement methods have gradually become a trend. At present, the experimental research on the optical measurement method of eye tissue has made certain progress. There are many optical biometers in clinical practice, but there are still immature parts, such as the inability to image the whole eye, the image needs to be stitched, and the types of measured parameters are not comprehensive. In response to the above problems, we proposes a high-resolution, large-range imaging, and high-precision optical biometric method. It provides a reliable method for the diagnosis and treatment of ophthalmic diseases.  

This paper develops a whole-eye tissue parameter measurement system based on swept frequency source optical coherence tomography technology, which is used for whole-eye imaging and accurate measurement of eye tissue parameters. The system uses a swept source laser with a center wavelength of 1060 nm based on the vertical cavity surface emitting laser technology as the light source, and integrates an internal fixation component and a video monitoring component. Scanning and synchronous sampling are controlled by the C++ programming system, and the collected data is uploaded to the computer through the data acquisition card for processing, obtaining the spatial structure information of the target organization, and generating 2D images.

This paper uses the whole-eye tissue parameter measurement system for pre-experiment and human eye tissue parameter measurement experiment. The preliminary experiment mainly measures the distance information calibrated everywhere in the simulated eye and the curvature information of the plano-convex lens. The human eye measurement experiment is mainly divided into the length measurement experiment to measure the axis length and the curvature measurement experiment to measure the corneal refractive power. In this paper, according to the eyeball structure and the refractive index theory of each tissue, the length and curvature are measured on the 2D image, and the data of the corresponding ocular tissue parameters are calculated. To verify the accuracy of the measurement system, the measurement result is compared with the measurement data 700 of IOL Master. Through linear regression analysis and evaluation, the measurement results of this system and IOL Master 700 have consistency, indicating that the developed whole-eye tissue parameter measurement system realizes the accurate measurement of ocular tissue parameters such as axial length and corneal curvature. It meets the requirements of clinical measurement and has potential application value in the diagnosis and prevention of ophthalmic diseases.