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论文题名(中文):

 自体肋软骨及多孔高密度聚乙烯(Medpor)材料临床应用系统评价分析    

姓名:

 邬丛笑    

论文语种:

 chi    

学位:

 硕士    

学位类型:

 专业学位    

学校:

 北京协和医学院    

院系:

 北京协和医学院整形外科医院    

专业:

 临床医学-外科学    

指导教师姓名:

 潘博    

论文完成日期:

 2021-04-19    

论文题名(外文):

 Systemic evaluation and analysis of clinical application of autogenous costal cartilage and porous high density polyethylene (MEDPOR)    

关键词(中文):

 小耳畸形 自体肋软骨 Medpor支架    

关键词(外文):

 microtia Autogenous costal cartilage Medpor    

论文文摘(中文):

目的:此次研究的主要目的是想通过对小耳畸形中最常用的两种材料:自体肋软骨及Medpor支架做一个综合的评价分析,在查询了既往的临床数据及文献之后,经由多个维度去比较二者的特性,分析二者的临床效果、安全性及并发症的发生率,用于为一线工作的整形外科医师提供参考资料,从而提高治疗的满意度和效果。

资料与方法:通过对Pubmed、Cochrane,Library、知网、万方医学等多个数据库进行检索,对从2008年3月1日至2021年3月1年己发表的相关文献进行归纳整理。按照一定的纳入、排除标准,通过对收集的文献进行数据分析及处理,以得出二者的临床应用情况以及并发症发生率等。

结果:最终纳入14篇2008-2021年间发表的回顾性观察性研究,其中包含4987患者。我们对所选文献中支架的术后感染发生率、软骨暴露发生率、血肿发生率、支架变形发生率、术后满意率进行归纳总结并分析。其中,Medpor支架治疗小耳畸形后的软骨暴露发生率显著高于自体肋软骨治疗(p=0.007),具有统计学意义。在感染、血肿发生、支架变形等并发症方面,统计结果表明二者无较大差异。

结论:自体肋软骨重建是小耳畸形传统的修复方法,与异体重建相比,肋软骨重建对创伤的反应最稳定,对感染也有抵抗力,由于取自人体,可以以较经济的方式获得充足的供体,并且没有免疫原性,排斥性低,远期效果可观,但对术者的雕刻要求较高。Medpor耳支架与自体软骨相比,它的手术时间较少,而且由于其标准化和精确的制造过程,往往更美观准确,但价格高昂,许多患者家庭难以负担,并且由于其作为异体植入所带来的术后感染以及支架的高暴露率,由于缺乏大样本远期随访,其疗效有待进一步观察。

论文文摘(外文):

Objective: The main purpose of this study was to examine the two most commonly used materials:Autogenous costal cartilage and Medpor bracket, through multiple dimensions to compare the characteristics of both and provide reference data and relevant information of auricle reconstruction for the frontline plastic surgeons, so as to reduce the incidence of side effects as far as possible, and then improve the satisfaction and effect of treatment。

Materials and Methods: Literature retrieval was conducted on PubMed, Cochrane, Library, Embase, CNKI and Wanfang Medical Spectator Database, and relevant literatures published from March 1, 2008 to March 1, 2021 were summarized and sorted。According to certain inclusion and exclusion criteria, Meta analysis was performed in combination with the literature that met the requirements。 According to the clinical application of autogenous costal cartilage and MedPor scaffold material, the complications and satisfaction were compared。

 Results: Fourteen retrospective observational studies, including 4987 patients, published between 2008 and 2021 were included。 The incidence of postoperative infection, cartilage exposure, hematoma, stent deformation and postoperative satisfaction rate of the stents in the selected literature were compared and analyzed。 Among them, the incidence of cartilage exposure after the treatment of microtia with Medpor stent was significantly higher than that with autogenous rib cartilage (P =0。007), which was statistically significant。 There was no significant difference in the complications of infection, hematoma and stent degeneration。

 Conclusion: Autogenous rib cartilage has the advantages of low rejection reaction, easy to take material, sufficient amount, easy to carve, flexibility, good histocompatibility, long-term stability, low infection rate, few complications, etc。, and satisfactory postoperative effect。 It is an ideal material for auricle reconstruction, and should be the first choice if there is no contraindication。 MedPOR ear stent has the advantages of easy assembly, good histocompatibility, easy vascular insertion, simple operation, time-saving operation, less trauma, ideal shape of reconstructed ear, etc。 However, the incidence of stent exposure is high and there is a risk of surgical failure。 Therefore, indications should be strictly controlled to prevent skin necrosis and stent exposure。 Due to the lack of long-term follow-up of large samples, its efficacy remains to be further observed。

开放日期:

 2021-06-16    

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