第一部分 血清高敏C反应蛋白与冠心病患者冠状动脉病变严重程度的相关性分析

目的：血清高敏C反应蛋白（High-sensitivity C-reactive protein，hs-CRP）是一种可以预测冠心病（Coronary artery disease， CAD）患者心血管事件风险的炎性指标。本研究目的为探讨冠心病患者血清hs-CRP水平与造影确定的冠状动脉狭窄严重程度的相关性。

方法：本研究纳入阜外医院连续住院的疑诊冠心病患者1594例，所有患者住院期间均接受血清hs-CRP检测和冠状动脉造影检查。根据冠状动脉狭窄分支的数目和Gensini评分评估冠状动脉动脉粥样硬化严重程度。造影未见冠脉狭窄或狭窄小于50%，即排除冠心病。Spearman偏相关回归分析评价hs-CRP水平与病变严重程度的相关性。

结果：与非CAD的患者相比，CAD患者血清hs-CRP水平显著增高（分别为1.63 mg/L和2.03mg/L，P < 0.001）。另外，血清hs-CRP水平随冠状动脉狭窄分支数目和Gensini评分增高而增高。在调整了其它混杂因素后，血清hs-CRP水平增高仍与Gensini评分呈显著相关（P = 0.006）。

结论： 对于疑诊冠心病的患者，血清hs-CRP水平是一个潜在的预测冠心病和冠状动脉病变严重程度的指标。

第二部分 踝臂指数与冠心病患者冠状动脉病变严重程度的相关性分析

摘要

目的：本研究目的为探讨冠心病患者的踝臂指数（Ankle-brachial index, ABI）与冠状动脉造影确定的冠状动脉病变严重程度的相关性。

方法：本研究纳入阜外医院连续住院的疑诊冠心病患者837例，所有患者住院期间均接受冠状动脉造影检查并测量ABI。根据冠状动脉狭窄分支数目和Gensini评分评估冠状动脉粥样硬化严重程度。评价ABI与冠脉病变严重程度的相关性。

结果：入选患者男性553例，女性284例，平均年龄59.31±9.85岁。ABI≤0.9组的三支病变和左主干病变的患者所占比例显著高于ABI>0.9组（60.3%对30.1%，P=0.001）。ABI与Gensini评分呈负相关关系，校正年龄、吸烟状况、血糖、血尿酸、甘油三酯、高敏C反应蛋白等混杂因素后，相关关系仍然存在（r=0.094，P=0.007）。

结论：对于疑诊冠心病的患者，ABI是一个潜在的预测冠状动脉病变严重程度的指标。

The Correlation Analysis for the Serum High-sensitivity

C-Reactive Protein Levels and Angiographic Severity of

Coronary Artery Disease

Abstract

Objectives: High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation that predicts cardiovascular events in patients of coronary artery disease (CAD). Our objective was to evaluate the correlation between serum levels of hs-CRP and the angiographic severity of coronary lesion.

Methods: Total 1594 consecutive hospitalized patients suspected CAD were enrolled. The serum level of hs-CRP and coronary angiography were performed in all participants. CAD was excluded when there was no angiography confirmed stenosis or stenosis less than 50%. The Spearman partial correlation analysis was used to evaluate the correlation between hs-CRP and severity of coronary artery disease, which was determined by the number of stenotic vessels and the Gensini score.

Results: The serum hs-CRP was significantly higher (2.03 mg/dl vs 1.63 mg/dl, P<0.001) in patients with CAD compared with nonCAG. The hs-CRP levels increased significantly with the increase of the number of the stenotic vessels and Gensini score. The increased serum hs-CRP were associated with Gensini score, even after the adjustment of confounding factors (P = 0.006).

Conclusions: For patients suspected CAD, The ABI could be a potential parameter to predict the CAD and the severity of coronary artery stenosis.

The Correlation Analysis for Ankle-Brachial Index and the Angiographic Severity of Coronary Artery Disease

Abstract

Objectives: To determine the correlation between ankle–brachial index (ABI) and the angiographic severity of coronary artery disease (CAD).

Methods: Total 837 consecutive hospitalized patients suspected CAD were enrolled. All patients underwent coronary artery angiography and ABI measurements. The relationship between ABI and the severity of CAD, which was determined by the number of stenotic vessels and the Gensini score, was evaluated.

Results: Of the included patients, 553 male and 284 female, with an average age of 59.31±9.85. The prevalence of triple vessel disease and left main lesion were significantly higher in ABI≤ 0.9 groups compared with patients of ABI > 0.9（60.3% vs. 30.1%，P=0.001）. There was a negative correlation between the ABI and the Gensini score, even after the adjustment of confounding factors such as age, smoking status, blood glucose, serum uric acid, triglyceride and high-sensitive c-reactive protein（r=0.094，P=0.007）.

Conclusions: The ABI could be a useful method in assessing the severity of coronary artery stenosis in patients suspected CAD.